Summary
Summary of my overall work. Recently, I discovered (Andrisse 2017) that the pathway towards insulin resistance and type 2 diabetes in a subset of females was different from the typical way (inactivity and overeating). The externally funded projects below seek to further understand this novel disease pathway and to find targeted therapies (advancing a growing field called personalized medicine).
Another discovery from my lab showed that lean and normal weight young women with polycystic ovary syndrome (PCOS) develop type 2 diabetes that is being underdiagnosed and ineffectively treated (Falzarano 2022). Across the field, black women have largely been left out of these studies that would improve their health (Andrisse 2021). Thus, my lab has a clinical project focused on improving the health of black women with PCOS by investigating the early detection of disease.
Another discovery from my lab showed that lean and normal weight young women with polycystic ovary syndrome (PCOS) develop type 2 diabetes that is being underdiagnosed and ineffectively treated (Falzarano 2022). Across the field, black women have largely been left out of these studies that would improve their health (Andrisse 2021). Thus, my lab has a clinical project focused on improving the health of black women with PCOS by investigating the early detection of disease.
We don’t just study metabolism; we study resilience—because every cell, like every person, has the potential for transformation."
FUNDED GRANTS AND CONTRACTS
Title: The cellular molecular regulation of differing mechanisms of insulin resistance.
Grant #: NIH 1R01DK126892
Years: July 2022 to June 2027 (5-year grant)
Project Summary: Insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin and can’t easily take up glucose from your blood, a condition known as prediabetes, affecting more than 84 million people ages 18 and older in the United States, about 1 out of every 3 adults. Researchers don’t fully understand what causes insulin resistance and prediabetes, but they think that excess weight and lack of physical activity are major factors. Here, we study three models of insulin resistance in an animal model to better understand the mechanisms involved in insulin resistance related to excess fat intake, excess sugar intake, and excess androgens.
Title: Bridges to the Baccalaureate Research Training Program at Howard University and Baltimore City Community College
Grant #: NIH 1T34GM142610
Years: Aug 2022 to July 2027 (5-year grant)
Project Summary: Bridges to Baccalaureate students would be recruited and provided educational readiness by Prison to Professionals while still incarcerated, transition to a 2-year associates granting school (Baltimore City Community College, BCCC), be provided skills and methods development during their 2-years at BCCC, participate in a 10-week STEM research internship at Howard (HU) University, then transition to a 4-year Bachelors granting school, HU. Thus, this project is taking the highly innovative approach to intersect the worlds of research, education, and incarceration by creating a ground-breaking prison-to-college-and-STEM pipeline.
Title: Analysis of hepatic Androgen Receptor (AR) knockdown for targeted treatment of Polycystic Ovary Syndrome (PCOS).
Contract #: GB-45025_Alnylam Pharmaceuticals
Years: Feb 2023 to Feb 2024 (1-year)
Project Summary: Genetic deletion of hepatic AR has been shown to be very effective in ameliorating the metabolic impact of PCOS in a mouse model using low-dose DHT (Andrisse 2021). The current study will use proprietary therapeutic compounds to prevent the development of insulin resistance in female mice.
Grant #: NIH 1R01DK126892
Years: July 2022 to June 2027 (5-year grant)
Project Summary: Insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin and can’t easily take up glucose from your blood, a condition known as prediabetes, affecting more than 84 million people ages 18 and older in the United States, about 1 out of every 3 adults. Researchers don’t fully understand what causes insulin resistance and prediabetes, but they think that excess weight and lack of physical activity are major factors. Here, we study three models of insulin resistance in an animal model to better understand the mechanisms involved in insulin resistance related to excess fat intake, excess sugar intake, and excess androgens.
Title: Bridges to the Baccalaureate Research Training Program at Howard University and Baltimore City Community College
Grant #: NIH 1T34GM142610
Years: Aug 2022 to July 2027 (5-year grant)
Project Summary: Bridges to Baccalaureate students would be recruited and provided educational readiness by Prison to Professionals while still incarcerated, transition to a 2-year associates granting school (Baltimore City Community College, BCCC), be provided skills and methods development during their 2-years at BCCC, participate in a 10-week STEM research internship at Howard (HU) University, then transition to a 4-year Bachelors granting school, HU. Thus, this project is taking the highly innovative approach to intersect the worlds of research, education, and incarceration by creating a ground-breaking prison-to-college-and-STEM pipeline.
Title: Analysis of hepatic Androgen Receptor (AR) knockdown for targeted treatment of Polycystic Ovary Syndrome (PCOS).
Contract #: GB-45025_Alnylam Pharmaceuticals
Years: Feb 2023 to Feb 2024 (1-year)
Project Summary: Genetic deletion of hepatic AR has been shown to be very effective in ameliorating the metabolic impact of PCOS in a mouse model using low-dose DHT (Andrisse 2021). The current study will use proprietary therapeutic compounds to prevent the development of insulin resistance in female mice.
Research is more than data and experiments—it’s a responsibility to create knowledge that serves humanity."
Andrisse LAb In ACtion
Summer 2022
EB 2022
Position/Trainee Types Available Annually:
Position/Trainee Types Available Annually:
Student Researcher-1 (part-time)
Research Technician (full time)
Graduate Research Assistant (full time PhD Student)
Postdoc (full time)
Minimum Education Requirement: High school diploma or GED for Student Researchers; Bachelors for Research Technicians and Graduate Research Assistants; Doctorate in relevant field for Postdocs
Applications: Rolling; Cover Letter, CV/resume, and list of references. Link to Application.
Supervisor: Dr. Stanley Andrisse, [email protected];
Department: Department of Physiology and Biophysics
College: Howard University College of Medicine
Position Description: Dr. Stanley Andrisse, an Assistant Professor in the Department of Physiology and Biophysics at Howard University College of Medicine, is looking for a research technician and/or trainee(s) (undergraduate students, graduate students, and postdocs) to help perform basic and molecular laboratory techniques such as, cell culture, transfections and transformations, protein and nucleic acid isolation, western blot analysis, immunoprecipitation, quantitative real-time PCR, animal colony maintenance, and others.
General Duties: Assemble, maintain and operate lab equipment. Assist in observing experiments and calculating and recording results from those experiments. Troubleshoot equipment problems. Examine laboratory animals and clean laboratory supplies. Collect samples for research and prepare specimens.
Research Interests: Dr. Andrisse’s research investigates the intersecting pathways of different insulin resistant states. Dysregulated hepatic glucose metabolism plays a pivotal role in the pathophysiology of metabolic syndrome, type 2 diabetes and insulin resistance. The pathways that regulate hepatic gluconeogenesis, glycogen synthesis, and glycogenolysis are complex. Increasing evidence from my work and others has revealed many intersecting pathways that influence the traditional PI3K/AKT insulin action pathway. Discovering these mechanistic interactions, using cutting-edge molecular technologies is the focus of my work. I will employ the use of animal models, cell culture models and clinical collaborations.
Preference will be given to candidates who have demonstrated: experience in basic and molecular laboratory techniques; excellence in oral and written communication skills; a commitment to and interest in advising students from diverse backgrounds; effective interpersonal and collaboration skills; an appreciation for the Howard mission; and the ability to contribute to a positive, collegial, work atmosphere.
A complete application consists of: (1) a 0.5-2 page cover letter that addresses (a) qualifications for the position (b) research interests or why you want to join this lab, and (c) career/personal goals, (2) a curriculum vitae or resume (no page limit), and (3) a list of three references. Letters of recommendation will be requested later. Candidates can apply to this position via the position link or by emailing Dr. Stan Andrisse directly, [email protected].
The Department of Physiology and Biophysics at Howard University College of Medicine has a talented and productive group of faculty who are committed to aggressively enhancing our department’s contributions to science, education and scholarly literature. Our Mission is to: (a) Provide students with an outstanding educational experience that prepares them for careers in the Health Professions, Biomedical Research, and Academia, (b) Conduct innovative and cutting-edge research that addresses vital issues related to human health and physiology, and (c) Advocate for excellence in education and healthcare for underrepresented populations.
Student Researcher-1 (part-time)
Research Technician (full time)
Graduate Research Assistant (full time PhD Student)
Postdoc (full time)
Minimum Education Requirement: High school diploma or GED for Student Researchers; Bachelors for Research Technicians and Graduate Research Assistants; Doctorate in relevant field for Postdocs
Applications: Rolling; Cover Letter, CV/resume, and list of references. Link to Application.
Supervisor: Dr. Stanley Andrisse, [email protected];
Department: Department of Physiology and Biophysics
College: Howard University College of Medicine
Position Description: Dr. Stanley Andrisse, an Assistant Professor in the Department of Physiology and Biophysics at Howard University College of Medicine, is looking for a research technician and/or trainee(s) (undergraduate students, graduate students, and postdocs) to help perform basic and molecular laboratory techniques such as, cell culture, transfections and transformations, protein and nucleic acid isolation, western blot analysis, immunoprecipitation, quantitative real-time PCR, animal colony maintenance, and others.
General Duties: Assemble, maintain and operate lab equipment. Assist in observing experiments and calculating and recording results from those experiments. Troubleshoot equipment problems. Examine laboratory animals and clean laboratory supplies. Collect samples for research and prepare specimens.
Research Interests: Dr. Andrisse’s research investigates the intersecting pathways of different insulin resistant states. Dysregulated hepatic glucose metabolism plays a pivotal role in the pathophysiology of metabolic syndrome, type 2 diabetes and insulin resistance. The pathways that regulate hepatic gluconeogenesis, glycogen synthesis, and glycogenolysis are complex. Increasing evidence from my work and others has revealed many intersecting pathways that influence the traditional PI3K/AKT insulin action pathway. Discovering these mechanistic interactions, using cutting-edge molecular technologies is the focus of my work. I will employ the use of animal models, cell culture models and clinical collaborations.
Preference will be given to candidates who have demonstrated: experience in basic and molecular laboratory techniques; excellence in oral and written communication skills; a commitment to and interest in advising students from diverse backgrounds; effective interpersonal and collaboration skills; an appreciation for the Howard mission; and the ability to contribute to a positive, collegial, work atmosphere.
A complete application consists of: (1) a 0.5-2 page cover letter that addresses (a) qualifications for the position (b) research interests or why you want to join this lab, and (c) career/personal goals, (2) a curriculum vitae or resume (no page limit), and (3) a list of three references. Letters of recommendation will be requested later. Candidates can apply to this position via the position link or by emailing Dr. Stan Andrisse directly, [email protected].
The Department of Physiology and Biophysics at Howard University College of Medicine has a talented and productive group of faculty who are committed to aggressively enhancing our department’s contributions to science, education and scholarly literature. Our Mission is to: (a) Provide students with an outstanding educational experience that prepares them for careers in the Health Professions, Biomedical Research, and Academia, (b) Conduct innovative and cutting-edge research that addresses vital issues related to human health and physiology, and (c) Advocate for excellence in education and healthcare for underrepresented populations.
